Niche may refer to:

• Niche (architecture), an exedra or an apse that has been reduced in size;
• Niche (footballer) (b. 1985), Colombian/Spanish football (soccer) player, full name Víctor Manuel Micolta Armero
• Ecological niche, a term describing the relational position of an organism's species
• Niche market, a focused, targetable portion (subset) of a market sector.
• Niche, an alternative name for Bassline (dance music)
• Stem cell niche
• NICHE (Nurses Improving Care for Healthsystem Elders) Program, an organization dedicated to creating a better care environment for hospitalized elderly patients

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